Fungitoxicity of m-fluorophenylalanine-containing peptides towards Pythium ultimum |
| |
Authors: | D H Young R J Mehta |
| |
Institution: | Rohm and Haas Co., Research Laboratories, Spring House, Pennsylvania 19477. |
| |
Abstract: | The tripeptide L-m-fluorophenylalanyl-L-alanyl-L-alanine was much more fungitoxic towards Pythium ultimum than the dipeptide L-m-fluorophenylalanyl-L-alanine or m-fluorophenylalanine. The fungitoxicity of the tripeptide was reduced by L-alanyl peptides and phenylalanine, but not by other amino acids. In contrast, the fungitoxicity of m-fluorophenylalanine was unaffected by peptides, and was antagonized by several amino acids. These results suggest the effective delivery of m-fluorophenylalanine into the cell by a tripeptide carrier. |
| |
Keywords: | |
|
|