| 儿童用氨基酸注射液的气质联用分析 |
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| 引用本文： | 张铁垣,徐蓓,陈维杰.儿童用氨基酸注射液的气质联用分析[J].北京师范大学学报(自然科学版),1987(2). |
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| 作者姓名： | 张铁垣 徐蓓 陈维杰 |
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| 作者单位： | 北京师范大学化学系，北京师范大学化学系，北京师范大学化学系 |
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| 摘 要： | 本文优选了氨基酸的衍生化条件,建立了全肠胃外营养(TPN)注射液中19种氨墓酸的气质联用分析方法,40min内可完成全分析,灵敏度达10~(-11)mol,比专用的氨基酸分析仪分析时间缩短了1/3,灵敏度提高了两个数量级;对氨基酸的衍生化反应及衍生物的质谱裂解机理进行了初步探讨。
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| 关 键 词： | 氨基酸注射液 七氟丁酰正丁酯衍生物 色谱质谱联用分析 裂解机理 |
ANALYSIS OF AMINO ACIDS INJECTION FOR INFANTS AND YOUNG CHILDREN BY GC/MS |
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| Zhang Tieyuan Xu Bei Chen Weijie.ANALYSIS OF AMINO ACIDS INJECTION FOR INFANTS AND YOUNG CHILDREN BY GC/MS[J].Journal of Beijing Normal University(Natural Science),1987(2). |
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| Authors: | Zhang Tieyuan Xu Bei Chen Weijie |
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| Institution: | Department of Chemistry |
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| Abstract: | The derivatization factors of protein amino acids for GLC analysis are studied and optimized, the analytical method of 19 protein amino acids in total patenteral nutrition (TPN)injection for infants and young children by GC/MS is established. The entire process can be completed within 40 min, i. e., 20 min shorter than the conventional amino acid anslyzer; a sensitivity of 10~(-11) mol is obtained, showing an improvement by two orders of magnitude. The derivatization of amino acids and the fragmentation mechanism of the derivative fragmentation product are also investigated. |
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| Keywords: | amino acid injection N (O)-heptafluobutyral-O-n-butyl derivative analysis by GC/MS combination fraganentation mechanism |
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