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Small changes in expression affect predisposition to tumorigenesis. |
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| Authors: | Hai Yan Zuzana Dobbie Stephen B Gruber Sanford Markowitz Kathy Romans Francis M Giardiello Kenneth W Kinzler Bert Vogelstein |
| Institution: | The Howard Hughes Medical Institute, The Oncology Center, and The Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA. |
| Abstract: | We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis. |
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