The autooxidation of 2,3,5,6-tetrahydroxy-2,5-cyclohexadiene-1,4-dione under physiological conditions |
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| Authors: | M. E. Hoffmann D. B. Ciampi N. Duran |
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| Affiliation: | (1) Instituto de Biologia, Departamento de Bioquimica, Universidade Estadual de Campinas, C.P.6154, CEP 13.100 Campinas, S.P., Brasil;(2) Instituto de Quimica, Laboratorio de Quimica Biologica, Universidade Estadual de Campinas, C.P.6154, CEP 13.100 Campinas, S.P., Brasil |
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| Abstract: | Summary A radical anion of 2,3,5,6-tetrahydroxy-2,5-cyclohexadiene-1,4-dione was detected using the EPR technique by complexing with Zn ions. Hydrogen peroxide, superoxide radical anion and hydroxyl radical were also detected in the reaction mixture. Kinetic study and product distribution indicated a probable mixed type one- and two-electron transfer mechanism. A possible relationship between the autooxidation process and the biological activity of substituted quinones was suggested. |
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| Keywords: | Oxygen activated species chemiluminescence quinones autooxidation radicals EPR |
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