5-Thio-d-glucose:o-diphenoloxidase inhibition as its mechanism of action

Summary 5-Thio-d-glucose completely inhibitedo-diphenoloxidase from animal as well as plant sources. It has been reported that thioglucose suppresses spermatogenesis in mice and also insect metamorphosis, probably through inhibition of glucose transport. Inhibition ofo-diphenoloxidase (which is active in spermatozoa and insect larvae) is suggested as an alternative mechanism of action of thioglucose.