| 合成辣椒素新工艺 |
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| 引用本文： | 刘菲,徐华,赵静,霍二福. 合成辣椒素新工艺[J]. 河南科学, 2014, 0(12): 2471-2473 |
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| 作者姓名： | 刘菲 徐华 赵静 霍二福 |
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| 作者单位： | 1. 河南省化工研究所有限责任公司，郑州 450052; 河南省科学院质量检验与分析测试中心，郑州 450008
2. 河南省化工研究所有限责任公司,郑州,450052 |
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| 摘 要： | 香草胺盐酸盐(3-甲氧基-4-羟基苄胺盐酸盐)为原料,经氢氧化钠脱去盐酸得到香草胺(3-甲氧基-4-羟基苄胺),充分干燥后,与正壬酰氯在中性条件下以二氯甲烷溶液为溶剂发生反应,粗产物过滤后,进行酸碱处理,从而得到产物.产物结构经气相色谱、红外光谱、核磁共振表征得以确认.此工艺制备方法具有条件温和、后处理操作方便和产品纯度高的特点,可以进行工业化放大.
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| 关 键 词： | 合成辣椒素 合成 |
New Process of Synthetic Capsaicin |
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| Liu Fei , Xu Hua , Zhao Jing , Huo Erfu. New Process of Synthetic Capsaicin[J]. Henan Science, 2014, 0(12): 2471-2473 |
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| Authors: | Liu Fei Xu Hua Zhao Jing Huo Erfu |
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| Affiliation: | Liu Fei, Xu Hua, Zhao Jing, Huo Erfu (1. Henan Chemical Industry Research Institute Co. Ltd., Zhengzhou 450052, China; 2. Quality Inspection and Test Center, Henan Academy of Sciences, Zhengzhou 450008, China) |
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| Abstract: | Synthetic capsaicin was synthesized in a new process by using Vanillylamine Hydrochloride（4-hydroxy-3-methoxybenzylamine hydrochloride）and sodium hydroxide as raw material,and water as solvent. After the roomtemperature reaction,the intermediate product,Vanillylamine（4-hydroxy-3-methoxybenzylamine）,would be fullydried and dissolved in dichloromethane. Then,N-Nonanoyl Chloride was added into the dichloromethane solution.The final product will be filtered and treated by acid and base. The product structure was characterized by GC,IRand NMR. The new process,which is a simple process under mild reaction condition with high product purity,canbe potentially utilized in industrial amplification. |
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| Keywords: | synthetic capsaicin synthesis |
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