| 侧脑室注射氟桂嗪对马桑内酯诱发大鼠皮层和海马痫样放电的抑制作用 |
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| 引用本文： | 张玉芹,王阿敬,胡谋先,邹飞.侧脑室注射氟桂嗪对马桑内酯诱发大鼠皮层和海马痫样放电的抑制作用[J].武汉科技大学学报(自然科学版),2000,23(1):97-100. |
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| 作者姓名： | 张玉芹 王阿敬 胡谋先 邹飞 |
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| 作者单位： | 1. 武汉科技大学医学院,武汉,430080
2. 同济医科大学,武汉,430030 |
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| 基金项目： | 国家自然科学基金!资助项目 (No.39330 2 10 ) |
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| 摘 要： | 采用皮层应用马桑内酯的方法致痫大鼠，观察侧脑室注射钙通道阻滞药氟桂嗪对致痫动物皮层脑电图、海马电图和皮层诱发电位的影响。结果显示，马桑内酯致痫时，皮层脑电图、海马电图发生痫样放电，皮层诱发电位呈高振幅变化。侧脑室注射氟桂嗪能明显地抑制致痫大鼠皮层诱发电位的振幅和脑电图、海马电图痫样放电。结果提示，氟桂嗪的抗癫痫作用与抑制中枢神经元Ｃａ＾２＋内流有关。
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| 关 键 词： | 脑室 氟桂嗪 海马 痫样放电 马桑内酯 大脑皮层 |
| 修稿时间： | 1999－11－05 |
Inhibitory Effects of Injection of Flunarizine into Lateral Cerebroventricle on Epileptiform Discharges Induced by Coriaria Lactone in Cerebral Cortex and Hippocampus of Rats |
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| ZHANG Yu-qin,WANG A-jing,HU Mou-xian,ZOU Fei.Inhibitory Effects of Injection of Flunarizine into Lateral Cerebroventricle on Epileptiform Discharges Induced by Coriaria Lactone in Cerebral Cortex and Hippocampus of Rats[J].Journal of Wuhan University of Science and Technology(Natural Science Edition),2000,23(1):97-100. |
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| Authors: | ZHANG Yu-qin WANG A-jing HU Mou-xian ZOU Fei |
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| Abstract: | In the experiments,application of coriaria lactone(CL)to cerebral cortex caused the epileptiform discharges in rats.The electrocorticogram(ECoG)and the electrohippocampalogram(EHG) and the evoked potentials of cerebral cortex were observed after the injection of calcium channel blocker flunarizine into lateral cerebroventricle.The results showed that the amplitude of the evoked potential and epileptiform discharges in cerebral cortex were obviously restrained.The inhibitory effect of flunarizine might be related to restraining the Ca 2 influx into neurons in central nervous system. |
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| Keywords: | intracerebroventricular injection flunarizine evoked potential electrocorticogram electrohippocampalogram |
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