细菌纤维素组织工程支架的仿生矿化研究

骨骼创伤已经成为当今影响人类健康的一大病症。因此,骨修复材料就成为研究的一大热点。骨组织工程支架作为重要的骨修复材料,可以诱导成骨细胞生长并为新骨生长提供条件。传统的骨组织工程支架包括合成高分子(如聚乳酸、聚乙醇酸等)和天然高分子(如胶原、壳聚糖等)。与传统支架材料相比,细菌纤维素(BC)具有良好的生物相容性、精细的纳米空间三维网络结构,有作为组织工程支架的潜能。通过仿生矿化处理,BC纳米纤维表面可以生长出羟基磷灰石(HA)的晶体颗粒,且HA颗粒均匀覆盖在纳米纤维表面。通过热分析得出,仿生矿化处理会使BC的热稳定性得到一定的提升。

Study on Biomineralization of Bacterial Cellulose Scaffold

Bone damage is a serious problem related to human's health.Hence,the study on bone repair materials has received considerable attention recently.Bone tissue engineering scaffold is an important bone repair material due to its capability to induce the growth of new bone tissue.There are two kinds of traditional scaffolds:synthetical polymers including PLA and PGA and natural polymers including collagen and chitosan.In comparison with traditional bone tissue scaffolds,Bacterial Cellulose(BC)has excellent biocompatibility and refined nano three dimensional network structures.In this work,the Hydroxylapatite(HA)crystal particles are formed and covered with BC nano fibrils uniformly via biomineralization method.The thermal stability of mineralized BC is enhanced accordingly.