亲水性分子印迹纳米球的合成及药物识别与释放性能研究

 以s-萘普生为模板分子（T），以甲基丙烯酸(MAA)为功能单体，甲基丙烯酸缩水甘油酯(GMA)为药物识别与释放的调节剂，二乙烯基苯（DVB）为交联剂，利用沉淀聚合法和环氧开环两步反应制备出亲水性的均匀球形纳米分子印迹聚合物。当n(T)∶n(MAA)∶n(GMA)∶n(DVB)=1∶4∶4∶24时制备的印迹聚合物粒径均一，单分散性好，平均粒径约832 nm，吸附实验表明该聚合物不仅可以在含水介质中对药物进行特异性识别，而且还具有良好的药物缓释性能。

Preparation of Hydrophilic Molecularly Imprinted Nano-spheres and the Properties on the Drug Release and Recognition

The orbicular molecularly imprinted polymer (OC MIP) was prepared by two steps including the precipitation polymerization and the opening the GMA epoxide ring. Then the hydrophilic external layer on the surface of OC MIP was formed. The OC MIP was characterized by infrared spectra and scanning electron microscopy (SEM). Water absorption measurement showed the OC MIP had stronger water compatible than MIP. When the proportion of MAA/GMA was 1∶〖KG-*2〗1, and DVB is 3 times of MAA co GMA, the particle shapes of MIPs were uniform and the recognition and release of OC MIP in polar solvent were satisfactory.The results showed GMA added in the polymers could adjust the capability of release of the polymers certainly. After the GMA epoxide ring was opened, OC MIP synthesized was more suitable to be employed in biological media because of the reduction of non specific hydrophobic interactions. In addition, the polymers had the capability of recognition, also could satisfy the study of both drug recognition and sustained release in polar solvent.