Experimental approaches to study functional recovery following cerebral ischemia |
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Authors: | Anu Lipsanen Jukka Jolkkonen |
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Institution: | (1) Institute of Clinical Medicine - Neurology, University of Eastern Finland, Yliopistonranta 1C, FI-70210 Kuopio, Finland;(2) Brain Research and Rehabilitation Center Neuron, Kortejoki, FI-71130 Kuopio, Finland; |
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Abstract: | Valid experimental models and behavioral tests are indispensable for the development of therapies for stroke. The translational
failure with neuroprotective drugs has forced us to look for alternative approaches. Restorative therapies aiming to facilitate
the recovery process by pharmacotherapy or cell-based therapy have emerged as promising options. Here we describe the most
common stroke models used in cell-based therapy studies with particular emphasis on their inherent complications, which may
affect behavioral outcome. Loss of body weight, stress, hyperthermia, immunodepression, and infections particularly after
severe transient middle cerebral artery occlusion (filament model) are recognized as possible confounders to impair performance
in certain behavioral tasks and bias the treatment effects. Inherent limitations of stroke models should be carefully considered
when planning experiments to ensure translation of behavioral data to the clinic. |
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