| 2-甲氧基-3-溴-5-硝基苯基苄基醚的合成方法研究 |
| |
| 引用本文： | 杨智麟,刘许歌,沈悦海.2-甲氧基-3-溴-5-硝基苯基苄基醚的合成方法研究[J].云南民族大学学报(自然科学版),2014,23(6):415-419. |
| |
| 作者姓名： | 杨智麟 刘许歌 沈悦海 |
| |
| 作者单位： | 昆明理工大学生命科学与技术学院,云南昆明,650500 |
| |
| 基金项目： | 国家自然科学基金，云南省自然科学基金 |
| |
| 摘 要： | 研究了安莎霉素类天然产物reblastatin芳核片段2-甲氧基-3-溴-5-硝基苯基苄基醚的合成方法.该合成路线的关键步骤是苯甲醛中间体的Baeyer-Villiger反应,此反应易生成羧酸副产物.通过对反应试剂和操作的优化,以84%的高产率获得了预期产物酚.该路线以5步直线步骤和33%的总收率实现了2-甲氧基-3-溴-5-硝基苯基苄基醚的制备.
|
| 关 键 词： | 2-甲氧基-3-溴-5-硝基苯基苄基醚 Baeyer-Villiger反应 Reblastatin |
Synthesis of 3-bromo-2-methoxy-5-nitrophenyl benzyl ether |
| |
| YANG Zhi-lin,LIU Xu-ge,SHEN Yue-hai.Synthesis of 3-bromo-2-methoxy-5-nitrophenyl benzyl ether[J].Journal of Yunnan Nationalities University:Natural Sciences Edition,2014,23(6):415-419. |
| |
| Authors: | YANG Zhi-lin LIU Xu-ge SHEN Yue-hai |
| |
| Institution: | YANG Zhi-lin;LIU Xu-ge;SHEN Yue-hai;Faculty of Life Science and Technology,Kunming University of Science and Technology; |
| |
| Abstract: | A synthesis of 3-bromo-2-methoxy-5-nitrophenyl benzyl ether,the aromatic fragment of ansamycin natural product reblastatin,was developed. The key reaction in this synthesis was a Baeyer-Villiger reaction of a benzaldehyde intermediate,as the undesired benzoic acid could be the major product in certain cases. After the optimization of reagents and operation,the desired phenol intermediate was obtained in 84% yield. This approachproduced 3-bromo-2-methoxy-5-nitrophenyl benzyl ether in 5 linear steps and 33% overall yield. |
| |
| Keywords: | 3-Bromo-2-methoxy-5-nitrophenyl benzyl ether Baeyer-Villiger reaction Reblastatin |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
