Kinetics and inotropic action of probenecid in guinea-pig heart in vitro |
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Authors: | R. R. Erttmann |
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Affiliation: | (1) Childrens Hospital, University of Hamburg, Martinistrasse 52, D-2000 Hamburg 20, (Federal Republic of Germany) |
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Abstract: | Summary Probenecid (100–750 g·ml–1) was found to inhibit cardiac contraction force in untreated and digoxin-treated (100 g·ml–1) isolated right guinea-pig atrium in vitro by a reversible process, without influencing beating frequency. At low concentrations (1.5–60 g·ml–1),14C-probenecid was accumulated into right atrium by an oxygen-dependent process. Correlation between uptake and negative inotropic action of probenecid could not be found. |
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