Serotonin is localized in endothelial cells of coronary arteries and released during hypoxia: A possible new mechanism for hypoxia-induced vasodilatation of the rat heart |
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| Authors: | G Burnstock J Lincoln E Fehér A M Hopwood K Kirkpatrick P Milner V Ralevic |
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| Institution: | (1) Department of Anatomy and Developmental Biology, and Centre for Neuroscience, University College London, Gower Street, WC1E 6BT London, (England);(2) First Department of Anatomy, Semmelweis University Medical School, Tüzolto u. 58, H-1450 Budapest, (Hungary) |
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| Abstract: | Summary In this report we demonstrate the immunocytochemical localization of serotonin in endothelial cells of rat coronary vessels and a significant increase in the release of serotonin into the perfusate of Langendorff rat heart preparations during hypoxia. It is suggested that serotonin, localized in endothelial cells, is released during hypoxia and could provide part of a pathophysiological mechanism for vasodilatation to protect the heart from damage due to hypoxia.This research was supported by the British Heart Foundation and the excellent technical assistance of Jon Bokor is gratefully acknowledged. |
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| Keywords: | Heart hypoxia serotonin endothelial cells |
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