太子健II缓解期防治小儿哮喘作用机理的实验研究

运用鸡卵蛋白致敏和反复诱喘的哮喘豚鼠模型,将豚鼠随机分为正常组、模型组、地塞米松组、高剂量和低剂量组5组,观察太子健II对其血及气道内嗜酸细胞浸润和血中白介素-5(IL-5)、嗜酸粒细胞阳离子蛋白(ECP)含量的影响.结果表明太子健II可减少哮喘豚鼠血及气道内EOS浸润,降低血中白介素-5(IL-5)和ECP的水平.说明太子健II可以减轻气道慢性变应性炎症,具有一定的抗哮喘复发的作用.

Experimental Study on Mechanism of Taizijian II in Anti-recurrence of Children Asthma

Using asthmatic model on guinea pigs in the experiment,forty guinea pigs were divided randomly into 5 groups as follows:normal group,model group,Taizijian II large dose group,Taizijian II small dose group and dexamethasone(DXM) group.The guinea pigs of the latter 4 groups were sensitized and induced asthmatic attack repeatedly every other day for 5 times with Egg Albumin and those of normal group were done with physiological saline.At the same time,the former 2 groups were treated with physiological saline and the latter 3 groups were treated respectively with Taizijian II in large dose,Taizijian II in small dose and DXM.And then we investigated the influence of Taizijian II on Eosinophils count(EC) in blood and airway,Eosinophil Cationic Protein(ECP) and Interleukin-5 in blood of asthmatic guinea pigs.The result was that Taizijian II could decrease EC,inhibit eosinophil recruitment in airway and decrease Interleukin-5 and ECP in blood to relieve the airway lesions.So Taizijian II could relieve the chronic allergic airway inflammation in asthmatic guinea pigs and stop asthma recurrence.