幼鼠呼吸道梗阻后前胸壁凹陷畸形

目的：探讨呼吸道梗阻后幼鼠胸廓形状的变化。方法：将60只4周龄SD（Sprague Dawley）大鼠随机分成留线组、除线组和对照组，每组20只，用1^#慕丝线绕颈段气管外围结扎固定除线组与留线组大鼠气管，术后第1、2、4、8、12周观察胸廓外观变化并于术后第12周行胸部CT扫描，除线组于术后第4周取出气管固定线。各组胸廓外观变化和前胸壁畸形发生率采用Х^2检验进行分析。结果：呼吸道梗阻大鼠术后出现前胸壁扁平，留线组和除线组分别有20％（4／20）和25％（5／20）发生前胸壁凹陷畸形，有统计学意义（P〈0．01），对照组无发生前胸壁畸形者。结论：呼吸道梗阻能导致生长发育期动物胸廓形状改变，甚至发生前胸壁的漏斗状畸形。

Anterior Chest Wall Depression Deformity after Airway Obstruction on Juvenile Rats

Objective: To present the changes of chest wall configuration in rats with airway obstruction.Methods: 60 Sprague Dawley(SD) rats of 4 weeks old were divided into 3 groups at random and there were 20 SD rats in each group respectively.A suture was tied round the trachea after anesthesia in group 1 and 2,no intervene was made in group 3 as the contrast.The tied suture were removed in group 2 four weeks later.They were fed for twelve weeks and the changes of chest wall configuration were recorded after operation.Data were analyzed with statistics by Chi-square test.Results: The occurrence rate of anterior chest wall depression deformity was 20% in group 1 and 25% in group 2 after operation with airway obstruction but no chest wall malformation took place in group 3.The differentiation was statistically significant(P<0.01).Conclusions: The data suggested that the changes of chest wall configuration and even the pectus deformity could be induced by airway obstruction in juvenile rats.