In vitro assay for human thyroid hormone receptor β agonist and antagonist effects of individual polychlorinated naphthalenes and Halowax mixtures |
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作者姓名: | SENTHIL KUMARAN Satyanarayanan |
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作者单位: | Unit;Toxicology;Bharathiar;University; |
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基金项目: | supported by the National Basic Research Program of China (2009CB421605); the National Natural Science Foundation of China (20877089 and 20737003) |
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摘 要: | Polychlorinated naphthalenes (PCNs) are dioxin-like environmental contaminants. There is growing concern over the endocrine-disrupting effects of PCNs, but very few studies have investigated the effect of PCNs on the thyroid system. This study used a yeast two-hybrid assay, which included the recombinant human thyroid receptor(TR)-β and reporter genes, to characterize the TRβ-disrupting effects of five individual PCN congeners, five PCN Halowax mixtures, and naphthalene. Their agonist and antagonist effects...
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关 键 词: | 甲状腺激素受体 多氯萘 激动剂 混合物 拮抗剂 测定 体外 拮抗活性 |
收稿时间: | 2006-06-23 |
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