首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells
Authors:J Allison  I L Campbell  G Morahan  T E Mandel  L C Harrison  J F Miller
Institution:Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Abstract:A class I histocompatibility gene, H-2Kb, linked to the rat insulin promoter, is overexpressed in the pancreatic beta cells of transgenic mice. The mice, whether syngeneic or allogeneic to the transgene, develop insulin dependent diabetes without detectable T cell infiltration, suggesting a direct, non-immune role for the transgenic class I molecules in the disease process.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号