| L-组氨酸不对称转化的研究 |
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| 引用本文： | 郭四化,吕俊,许文松.L-组氨酸不对称转化的研究[J].东北师大学报(自然科学版),2005,37(3):49-52. |
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| 作者姓名： | 郭四化 吕俊 许文松 |
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| 作者单位： | 浙江大学材料与化工学院,浙江,杭州,310027;浙江大学材料与化工学院,浙江,杭州,310027;浙江大学材料与化工学院,浙江,杭州,310027 |
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| 摘 要： | L-组氨酸(L-His)在醛的催化下,在羧酸溶剂中能发生消旋.当反应温度升高时,消旋反应速率加快.L-His用(R)-酒石酸((R)-TA)做拆分试剂,在乙酸溶剂中、水杨醛存在下进行不对称转换,合成了D-组氨酸(D-His)的酒石酸盐,经处理得到D-His.在最佳工艺条件下的收率为95.76%,光学纯度大于99.5%.
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| 关 键 词： | L-His D-His 消旋 不对称转换 |
| 文章编号： | 1000-1832（2005）03-0049-04 |
| 收稿时间： | 2004-08-28 |
| 修稿时间： | 2004年8月28日 |
Studies on asymmetric transformation of L-histidine |
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| GUO Si-hua,LU Jun,XU Wen-song.Studies on asymmetric transformation of L-histidine[J].Journal of Northeast Normal University (Natural Science Edition),2005,37(3):49-52. |
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| Authors: | GUO Si-hua LU Jun XU Wen-song |
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| Abstract: | L-Histidine (L-His) could be racemized in carboxylic acids which were used as solvents in presence of catalyst such as butanal .The rate of racemization of L-His increased with the increase of the temperature. The water in carboxylic acid decreased the rate of racemization. An asymmetric transformation from L-His to D-His through formation of salt with (R)-tartaric acid was achieved by using salicylaldehyde as a catalyst for epimerization in acetic acid, and D-His (R)-TA salt was obtained, treatment of the salt gave D-His with optical purity 100% in 95.76% yield based on the starting material under the optimistic conditions. |
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| Keywords: | L-His D-His |
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