| 三七总皂苷滴丸制备工艺研究 |
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| 引用本文： | 金杨,王燕,鲍家科.三七总皂苷滴丸制备工艺研究[J].大理学院学报,2010,9(8). |
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| 作者姓名： | 金杨 王燕 鲍家科 |
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| 作者单位： | 大理州中医医院;大理学院药学院;贵州省药品检验所; |
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| 摘 要： | 目的:确立三七总皂苷滴丸的最佳成型工艺.方法:先采用单因素实验以溶散时限、圆整度、沉降情况、硬度、拖尾情况并结合工业生产实际优选滴丸成型工艺条件;再采用L9(34)正交试验法,以重量差异变异作为评价指标,优选出滴丸的滴制条件,从而得出最佳成型工艺.结果:最佳制备工艺为:聚乙二醇-6000为基质,药物与基质配比为1:6,药液温度(70±1)℃,液体二甲硅油为冷却剂,滴头内外径(mm)比2.5:3.5,滴速65滴/min,滴距6cm,冷却剂温度(8±1)℃.结论:该成型工艺稳定、重现性好,所得制剂成型性好,质量指标符合2005年版<中国药典>滴丸剂质量标准.
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| 关 键 词： | 三七总皂苷滴丸 成型工艺 聚乙二醇 正交试验 |
Study on Preparation Process of Panax Notoginseng Saponins Droping Pills by Orthogonal Design |
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| JIN Yang,WANG Yan,BAO Jiake.Study on Preparation Process of Panax Notoginseng Saponins Droping Pills by Orthogonal Design[J].Journal of Dali University,2010,9(8). |
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| Authors: | JIN Yang WANG Yan BAO Jiake |
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| Institution: | JIN Yang1,WANG Yan2,BAO Jiake3(1.Traditional Chinese Medicine Hospital of Dali Prefecture,Dali,Yunnan 671000,China,2.College of Pharmacy,Dali University,3.Pharmaceutical Inspect Institute of Guizhou Province,Guiyang 550004,China) |
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| Abstract: | Objective: To obtain the optimal forming technology of panax notoginseng saponins droping pills.Methods: The optimum conditions of preparation process of total saponins from panax notoginseng droping pills were selected by single-factor with dissolution,integrality,subside,hardness,trail condition and were in connection with industrial production practice;then L9(34) orthogonal design was adopted and weight variation was used as evaluation indicator to select good dropping conditions for obtaining the optim... |
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| Keywords: | Panax notoginseng saponins droping pills forming technology polyethylene glycol orthogonal design |
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