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Immunomodulating effects in vitro of a hydroxythiazolobenzimidazole in the absence of mitogenicity
Authors:G. H. Warren  L. Mills  H. Friedman
Affiliation:(1) Departments of Microbiology, Wyeth Laboratories, Inc., P.O. Box 8299, 19101 Philadelphia, (Pennsylvania), (USA);(2) Albert Einstein Medical Center, 19141 Philadelphia, (Pennsylvania), (USA)
Abstract:Summary Wy-13, 876, a hydroxythiazolobenzimidazole, enhanced in vitro antibody formation by mouse spleen cells immunized with sheep red blood cells. The optimal dose was 25–50 mgrg/culture. The compound did not have a mitogenic effect at any dose.
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