Cholinergic components in the gastrin pathway of gastric acid stimulation

Summary In the isolated whole stomach of the mouse, cimetidine and atropine appear to be specific antagonists of histamine- and acetylcholine-induced stimulation of parietal cells. Interactions were demonstrated between cimetidine and gastrin, atropine and gastrin, respectively. In addition to a histaminergic pathway of gastrin stimulation, a cholinergic part, probably postganglionic, can be taken into consideration.Acknowledgments. I am indebted to Miss G.B. Bishop for her help with the English translation.