| 用神经网络方法对卡巴醌系列抗肿瘤药物的QSAR研究 |
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| 引用本文： | 卫连虎,乔园园,张卫东,周秀中,林少凡. 用神经网络方法对卡巴醌系列抗肿瘤药物的QSAR研究[J]. 南开大学学报(自然科学版), 2000, 33(2): 15-18 |
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| 作者姓名： | 卫连虎 乔园园 张卫东 周秀中 林少凡 |
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| 作者单位： | [1]南开大学中心实验室,天津 [2]南开大学化学系,天津 |
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| 摘 要： | 运用人工神经网络方法研究了卡巴醌（Ｃａｒｂｏｑｕｏｎｅ）系列药物对用Ｌ－１２０１白血病细胞接种的小鼠延长生命的活性，与传统的回归方法进行比较，可得到更为精确的结果，并且在活性预测方面有很好的效果。
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| 关 键 词： | 神经网络 定量构效关系 卡巴醌 抗肿瘤药物 QSAR |
| 修稿时间： | 1999-09-22 |
THE QSAR STUDY OF CARBOQUONE SERIALS ANTITUMOR DRUG USING ARTIFICIAL NEURAL NETWORK |
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| Wei Lianhu,Qiao Yuanyuan,Zhang Weidong,Zhou Xiuzhong,Lin Shaofan. THE QSAR STUDY OF CARBOQUONE SERIALS ANTITUMOR DRUG USING ARTIFICIAL NEURAL NETWORK[J]. Acta Scientiarum Naturalium University Nankaiensis, 2000, 33(2): 15-18 |
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| Authors: | Wei Lianhu Qiao Yuanyuan Zhang Weidong Zhou Xiuzhong Lin Shaofan |
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| Abstract: | In this paper, the method of Artificial Neural Network is used to study the activity of derivatives of Carboquone, prologing the life of mouse inoculated against L 1201 Leukaemic cell. And comparison with the method of traditional regression is also performed. It is also successful in forecasting the activity of unknown compound. |
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| Keywords: | Artificial Neural Network QSAR Carboquone |
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