| 大鼠心肌缺血模型在环境毒理学中应用的探讨 |
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| 引用本文： | 罗冬根. 大鼠心肌缺血模型在环境毒理学中应用的探讨[J]. 华东师范大学学报(自然科学版), 1999, 0(4): 93-98 |
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| 作者姓名： | 罗冬根 |
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| 作者单位： | 华东师范大学环境科学与技术系!上海200062 |
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| 摘 要： | 结扎大鼠左冠状动脉的左室支，造成局部心肌缺血，大体标本活性体染色与光镜检查的结果相符合，均显示缺血中心区大部分心肌梗塞，变性；缺血损伤在导致心电图紊乱的同时，还使心肌组织的脂质过氧化产物丙二醛大量生成和自由基清除剂超氧化物歧化酶的活性显著下降；
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| 关 键 词： | 心肌缺血 环境毒理学 铅 心脏 毒性 心率失常 |
A Study of Application of a Rat Myocardial IschemiaModel in the Environmental Toxiology |
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| Luo Donggen Zhang Ye Liu Yun Weng Enqi. A Study of Application of a Rat Myocardial IschemiaModel in the Environmental Toxiology[J]. Journal of East China Normal University(Natural Science), 1999, 0(4): 93-98 |
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| Authors: | Luo Donggen Zhang Ye Liu Yun Weng Enqi |
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| Abstract: | A model of myocardial ischemia is induced by coronary artery ligation in rats. Microscope observation and pathological dyeing showed that myocardial iinfarction occurs in the ischemic-centure area. Myocardial ischemia not only causes cardiac arrthythmmias but also increases the products of lipid peroxidation. The leakage of myocardial CPK demonstrated the results. It can be concluded that the myocardial ischemia model induced by coronary artery ligation is stable and reliable. The effect of Lead on heart by using the model was also checked, which showed that the toxicity of acute Lead load on the ischemic heart is obvious. Key words rat myocardial ischemia myocardial infarct creatine phosphate kinase arrthythmias malon-dialdehyde superoxide dismutase lead loadr MDOF is proposed. |
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| Keywords: | evolutionary spectrum dynamical criterion of first passage the system dynamical reliability. |
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