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p-Xylylenedicyanide and related compounds,weakly cytotoxic nitriles |
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| Authors: | J A Nicholson C H Jarboe W Haddon F W McLafferty |
| Institution: | (1) Pharmacology Department, School of Medicine, University of Louisville, 40202 Kentucky;(2) Chemistry Department, Purdue University, USA West Lafayette, Indiana |
| Abstract: | Zusammenfassung Extrakte vonV. opulus von schwacher Zelltoxizität enthaltenp-Xylylendinitril. Die Isomeren,m- undp-Cyanohydrozimtsäurenitrile, wurden synthetisiert und auf ihre zelltoxischen Eigenschaften hin untersucht:p-Xylylendinitril erweist sich als am stärksten wirksam. The reported work was supported in part by grants Nos. AM 07147, FR 00354, GM 12755 and GM 33888 from the United States Public Health Service, National Institutes of Health. We are grateful to the management and staff of the Isaac Bernheim Foundation for their helpful assistance with plants. Inquiries on mass spectra should be directed to F.W.M.; all other inquiries should be directed to C.H.J. |
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