一种医疗机构制剂的传统生产工艺

建立一种使用传统工艺配制医疗机构制剂——吉祥止咳膏的生产工艺标准，饮片采用饮用水煎煮提取3次，时间依次为2 h，2 h，1 h，该条件下提取率（干浸膏）达96.21%.将3次提取液过滤后合并，置于低温热回流提取浓缩设备中浓缩得到相对密度1.15~1.25的清膏.称取适量冰糖加水熬制糖浆，糖浆沸腾时呈蜂窝状，在糖浆相对密度大于1.4（80 ℃）时加入清膏（清膏与糖浆质量比1∶1.5），常压收膏，浓缩成相对密度1.25~1.40的膏滋，添加0.1%山梨酸钾，灌装.吉祥止咳膏的煎煮提取、浓缩、炼糖、收膏等工艺与制剂室生产设备相适应，属于传统工艺配制的中药制剂，成品质量稳定，符合要求，可在医院制剂室生产；配制流程稳定简便、重现性好，是生产吉祥止咳膏的有效方法.

Study on Traditional Medicinal Preparation Technology of Jixiang Cough Ointment

The standard for traditional medicinal preparation technology of Jixiang cough ointment has been established.The extraction rate (dry extract) reached 96.21% through three times of decoction with drinking water for 2 hours,2 hours,and 1 hour respectively.The extracts were filtered and combined for three times,and concentrated in the low-temperature hot reflux extraction and concentration equipment to obtain clear paste with a relative density of 1.15~1.25.A proper amount of rock sugar was boiled with water to make honeycomb-like syrup.When the relative density of syrup was greater than 1.4 (80 ℃),clear paste was added (the ratio of clear paste to syrup was 1∶1.5),and the paste was collected at normal pressure.The paste was concentrated with relative density 1.25~1.40,with addition of 0.1% potassium sorbate,and then was encapsulated.The extraction,concentration,sugar refining,paste collection,and paste collecting processes of Jixiang cough ointment are compatible with the equipments in the preparation room.It is a traditional Chinese medicinal preparation.The quality of the finished products is stable and meets the requirements,and it can be produced in the hospital preparation room.The preparation process is stable,simple,reproducible,and effective.