| 模拟失重条件下复合活菌制剂对肠道双歧杆菌的影响 |
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| 引用本文： | 郑永军,董海胜,孙琦,武艳萍,张淑静,臧鹏.模拟失重条件下复合活菌制剂对肠道双歧杆菌的影响[J].北京工商大学学报(自然科学版),2016,34(4):50-53. |
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| 作者姓名： | 郑永军 董海胜 孙琦 武艳萍 张淑静 臧鹏 |
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| 作者单位： | 中国人民解放军第二六一医院, 北京 100094,中国航天员科研训练中心 航天营养与食品工程重点实验室, 北京 100094,中国人民解放军第二六一医院, 北京 100094,中国航天员科研训练中心 航天营养与食品工程重点实验室, 北京 100094,中国航天员科研训练中心 航天营养与食品工程重点实验室, 北京 100094,中国航天员科研训练中心 航天营养与食品工程重点实验室, 北京 100094 |
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| 基金项目： | 航天营养与食品工程重点实验室预先研究课题(SYFD130041824)。 |
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| 摘 要： | 本研究采用-6°头低位卧床方法,模拟失重效应,通过观察和比较30d卧床期间不同时间节点,受试者便样中双歧杆菌含量的变化,探讨食用复合活菌制剂对模拟失重条件下肠道中双歧杆菌数量降低的拮抗效果,为制定航天员肠道菌群失调调节方案提供技术支持。14名健康男性受试者,随机分为对照组、食用活菌制剂组,每组7人。对照组仅-6°头低位卧床,在30d卧床期间第15天开始食用安慰剂,食用活菌制剂组于30d卧床期间第15天开始每日口服活菌制剂。实验期间定期采集便样测定双歧杆菌数目。实验表明,对照组及食用活菌制剂组在卧床初期便样中双歧杆菌数量均显著降低(p<0.05)；卧床期间,食用复合活菌制剂组与对照组相比,双歧杆菌水平差异显著(p<0.05)。30d头低位卧床可引起双歧杆菌数量显著下降,这提示模拟失重导致肠道菌群失调,食用复合活菌制剂可在一定程度上促进双歧杆菌的增殖,能够拮抗模拟失重致肠道菌群失调。
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| 关 键 词： | 模拟失重 复合活菌制剂 双歧杆菌 菌群失调 |
| 收稿时间： | 2015/5/27 0:00:00 |
Effects of Compound Probiotics on Intestinal Bifidobacteria Under Simulated Weightlessness |
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| ZHENG Yongjun,DONG Haisheng,SUN Qi,WU Yanping,ZHANG Shujing and ZANG Peng.Effects of Compound Probiotics on Intestinal Bifidobacteria Under Simulated Weightlessness[J].Journal of Beijing Technology and Business University:Natural Science Edition,2016,34(4):50-53. |
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| Authors: | ZHENG Yongjun DONG Haisheng SUN Qi WU Yanping ZHANG Shujing and ZANG Peng |
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| Institution: | Chinese People''s Liberation Army 261 Hospital, Beijing 100094, China,Key Lab of Space Nutrition and Food Engineering, Astronaut Scientific Research and Training Center of China,Beijing 100094,China,Chinese People''s Liberation Army 261 Hospital, Beijing 100094, China,Key Lab of Space Nutrition and Food Engineering, Astronaut Scientific Research and Training Center of China,Beijing 100094,China,Key Lab of Space Nutrition and Food Engineering, Astronaut Scientific Research and Training Center of China,Beijing 100094,China and Key Lab of Space Nutrition and Food Engineering, Astronaut Scientific Research and Training Center of China,Beijing 100094,China |
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| Abstract: | In this study, weightlessness was simulated by -6° head down tilt position. The test of 30d head-down tilt (HDT) bed rest was used to investigate the effects of compound probiotics on gut Bifidobacteria. Fourteen health males were subjects, who were divided into the control group and probiotics group. The control group had placebo while the probiotics group had the compound probiotics on the fifth day. The results showed that Bifidobacteria amounts significantly (p<0.05) decreased during the initial period while the compound probiotics could significantly (p<0.05) increased the Bifidobacteria amounts compared with the control group. Compound probiotics could increase the Bifidobacteria amounts to inhibit the microflora dysbiosis induced by simulated weightlessness. |
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| Keywords: | simulated weightlessness compound bacterium preparation Bifidobacteria microflora dysbiosis |
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