Electrocorticographic activity induced by gamma hydroxybutyrate in the rat during ontogenesis |
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Authors: | R. Rokyta P. Mareš P. Sobotka |
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Affiliation: | (1) Institute of Pathophysiology, Faculty of Medicine, Charles University, Lidická 1, 301 67 Plze , (CSSR);(2) Institute of Physiology, Czechoslovak Academy of Sciences, Víde ská 1083, 142 20 Prague, (Czechoslovakia) |
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Abstract: | Summary GHB at a dose of 200 mg·kg–1 i.p. elicited groups of slow waves with a frequency of 4–5 Hz in both frontal and occipital ECoG leads in adult rats. In 25- and 18-day-old rats similar slow wave activity became continuous and exhibited a clear-cut maximum in the frontal regions. In 15- and 12-day-old animals slow wave activity was also registered in the frontal region but it was organized into short groups of unstable frequency. No ECoG effects of GHB could be found in 9-day-old rats. |
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