| 前列腺素光化学前体：（1R，5S）-3-羟基二环[3,1,0]己基-6-基（苯基）甲酮的二维核磁表征 |
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| 引用本文： | 张成路,许皓添,李元东,周龙,邵懿,曲瑞峰,高丽娜. 前列腺素光化学前体：（1R，5S）-3-羟基二环[3,1,0]己基-6-基（苯基）甲酮的二维核磁表征[J]. 辽宁师范大学学报(自然科学版), 2012, 0(1): 69-72 |
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| 作者姓名： | 张成路 许皓添 李元东 周龙 邵懿 曲瑞峰 高丽娜 |
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| 作者单位： | 辽宁师范大学化学化工学院 |
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| 基金项目： | 辽宁省教育厅高校科研项目(2009A426);辽宁省教育厅创新团队项目(2008T107) |
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| 摘 要： | 以二环[3,1,0]己烷为骨架设计前列腺素光化学前体的反应路线,经过10步反应合成了具有NorrishⅡ型光化学特点的光化学反应前体目标产物.通过MS、HPLC、1 H NMR、13C NMR和DEPT 135等手段的表征了该化合物的一维结构,并且利用二维核磁共振技术1 H-1 H COSY、HSQC、HMBC、ROESY和NOE等手段对所合成目标产物的二维结构物进行了测定,确定了目标产物的空间结构.
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| 关 键 词： | NorrishⅡ型光化学反应 二环[3,1,0]己烷 核磁共振波谱 |
The characterization of the precursor of prostaglandin:(1R,5S)-3-Hydroxy bicyclo [3,1,0] hexan-6-yl(phenyl) methanone by two dimensional NMR |
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| ZHANG Cheng-lu,XU Hao-tian,LI Yuan-dong,ZHOU Long, SHAO Yi,QU Rui-feng,GAO Li-na. The characterization of the precursor of prostaglandin:(1R,5S)-3-Hydroxy bicyclo [3,1,0] hexan-6-yl(phenyl) methanone by two dimensional NMR[J]. Journal of Liaoning Normal University(Natural Science Edition), 2012, 0(1): 69-72 |
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| Authors: | ZHANG Cheng-lu XU Hao-tian LI Yuan-dong ZHOU Long SHAO Yi QU Rui-feng GAO Li-na |
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| Affiliation: | (School of Chemistry and Chemical Engineering,Liaoning Normal University,Dalian 116029,China) |
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| Abstract: | A reasonable synthetic route was designed based on bicyclo hexane skeleton.Norrish II type photochemical precursor(1R,5S)-3-hydroxyl bicycle hexan-6-yl)(phenyl) methanone target product was successfully synthesized through ten steps.The one-dimensional structure of target product was determined by means of MS、HPLC、1H NMR、13C NMR and DEPT 135.The two-dimensional structure of target product was determined by means of 1H-1H COSY、HSQC、HMBC、ROESY and NOE. |
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| Keywords: | Norrish Ⅱ type photochemical reaction bicyclo hexane nuclear magnetic resonance spectroscopy |
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