Altered or increased transfer-RNA methylation in the course of Interferon action on cells in culture? |
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| Authors: | H. Koblet R. Wyler U. Kohler |
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| Affiliation: | (1) Institute of Medical Microbiology, University of Berne, Friedbühlstrasse 51, CH-3008 Berne;(2) Institute of Virology, University of Zurich, Winterthurerstrasse 266 A, CH-8057 Zürich, (Switzerland);(3) Present address: Institute of Medical Microbiology, University of Berne, Switzerland;(4) Present address: Institute of Virology, University of Zurich, Switzerland |
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| Abstract: | Summary The induction of the antiviral state by Interferon might reflect the decrease of the rate of biosynthesis, the degradation or the alteration of one or several tRNAs. This could result in rate-limiting concentrations for codons common in viral RNA but rare in host mRNA. Altered methylation of tRNA could be the basis of such a phenomenon. However, we could not find an altered extent of methylation of total tRNA or an altered pattern of methylation, if mixed tRNAs were chromatographed on MAK- or BD-cellulose columns, despite a large range of conditions of pretreatment of chick embryo fibroblast cultures with interferon.Work supported by the Swiss National Science Foundation, grants 3.1050 and 3.540. |
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