Translating tissue-engineered tracheal replacement from bench to bedside |
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Authors: | Madhuri Kalathur Silvia Baiguera Paolo Macchiarini |
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Institution: | (1) BIOAIR Lab, Department of General Thoracic and Regenerative Surgery and Intrathoracic Biotransplantation, University Hospital Careggi, Largo Brambilla 3, 50134 Florence, Italy; |
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Abstract: | There are a variety of airway diseases with different clinical settings, which may extend from a surgical approach to total
organ replacement. Tissue engineering involves modifying cells or tissues in order to repair, regenerate, or replace tissue
in the body and seems to be a promising approach for airway replacement. The successful implantation of stem-cell-based tissue-engineered
trachea in a young woman with end-stage post-tuberculosis left main bronchus collapse serves as a prototype for the airway
tissue-engineered-based approach. The trachea indeed could represent a perfect model system to investigate the translational
aspects of tissue engineering, largely due to its low-oxygen needs. This review highlights the anatomy of the airways, the
various disease conditions that cause damage to the airways, elaborates on the essential components of the tissue-engineering
approach, and discusses the success of the revolutionary trachea transplantation approach. |
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Keywords: | |
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