| 邻硝基苯胺还原关环一步法合成苯并咪唑类化合物 |
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| 引用本文： | 朱洪,黄文忠,浦家齐. 邻硝基苯胺还原关环一步法合成苯并咪唑类化合物[J]. 上海大学学报(自然科学版), 2007, 13(1): 77-81 |
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| 作者姓名： | 朱洪 黄文忠 浦家齐 |
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| 作者单位： | 上海大学理学院,上海,200444;上海大学理学院,上海,200444;上海大学理学院,上海,200444 |
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| 摘 要： | 邻硝基苯胺( 1〖STBZ〗, 4〖STBZ〗)与芳香醛( 2〖STBZ〗〖WTHZ 〗a 〖WTHZ〗c )在连二亚硫酸钠存在下共热，发生还原关环反应， 一步即可合成苯并咪唑类化合物( 3〖STBZ〗〖WTHZ〗a 〖WTHZ〗c〖WTBZ 〗, 5〖STBZ〗〖WTHZ〗a 〖WTHZ〗c ).当起始物中含有不止一 个 硝基时，连二亚硫酸钠对硝基的还原有选择性.反应以乙醇 水为溶剂，水可加速反应进程.
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| 关 键 词： | 苯并咪唑 硝基化合物 连二亚硫酸钠 选择性还原 环化反应 |
| 文章编号： | 1007-2861（2007）01-0077-05 |
| 收稿时间： | 2006-05-16 |
| 修稿时间： | 2006-05-16 |
Synthesis of Benzimidazoles from o-Nitroanilines in a One-Step Reductive Cyclization Process |
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| ZHU Hong,HUANG Wen-zhong,PU Jia-qi. Synthesis of Benzimidazoles from o-Nitroanilines in a One-Step Reductive Cyclization Process[J]. Journal of Shanghai University(Natural Science), 2007, 13(1): 77-81 |
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| Authors: | ZHU Hong HUANG Wen-zhong PU Jia-qi |
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| Affiliation: | School of Sciences, Shanghai University, Shanghai 200444, China |
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| Abstract: | Benzimidazoles(3a-c,5a-c) were synthesized in a one step reductive cyclization reaction of(o-nitroanilines)(1,4) and aryl aldehydes(2a-c).Sodium dithionite was used as a reductive reagent.Selectivity was found when more than one nitro group existed in the substrates.A mixture of ethanol and water was used as solvent.The reaction was accelerated by water. |
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| Keywords: | benzimidazole nitro compound sodium dithionite selective reduction cyclization |
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