微波辐射相转移催化合成环丙烷氨基酸

以KOH-K2CO3作碱，Al2O3为外溶，以四丁基溴化铵（TBAB）为相转移催化剂，采用微波辐射干反应技术实现醛亚胺PhCH=NCH2CO2Et与1，2-二溴乙烷的串联烷基化反应，最佳反应条件为：醛亚胺3mmol，二溴乙烷5.7mmol,TBAB0.6mmol，KOH7mmol，K2CO314mmol，以Al2O3作外浴，微波辐射功率240W，微波辐射时间1min，产率56%。

Synthesis of 1-Aminocyclopropanecarboxylic Acid under Microwave Irradiation and Phase Transfer Catalysis

The synthesis of 1 Aminocyclopropanecarboxylic Acid(ACC) was performed by tandem alkylation of 1,2 dibromoethane and ethyl N (phenylmethylene) glycinate under solvent free condition coupled with microwave irradiation and phase transfer catalysis The optimum reaction conditions are as follows: an external alumina bath is used, aldimine 3 mmol, 1,2 dibromoethane 5 7 mmol, TBAB 0 6 mmol, KOH 7 mmol, K 2CO 3 14 mmol, microwave power 240 W and 1 min of microwave irradiation The production rate is 56%