| 腾冲嗜热厌氧菌的超氧化物歧化酶的进化踪迹分析 |
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| 引用本文： | 刘元东,刘楚干,丁建南,邱冠周.腾冲嗜热厌氧菌的超氧化物歧化酶的进化踪迹分析[J].湖南师范大学自然科学学报,2007,30(4):110-113. |
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| 作者姓名： | 刘元东 刘楚干 丁建南 邱冠周 |
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| 作者单位： | 1. 中南大学资源加工与生物工程学院,中国,长沙,410083
2. 湖南省新宁县崀山镇中心小学,中国,邵阳,422702 |
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| 基金项目： | 国家基础研究基金资助项目(2004CB619201)，国家自然科学基金资助项目(50321402) |
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| 摘 要： | 通过同源模建和分子动力学模拟,一个由腾冲嗜热厌氧菌的sod基因编码的蛋白质的可靠的分子结构被建立.对建立的结构进行进化踪迹分析识别出了11个踪迹残基.在它们当中,残基Asn36,Gly101和Glu158的位置遍布整个结构,无规可循;其余的残基都明显地聚于一个靠近铁原子的子类当中.这些结果表明,该基因编码含铁的超氧化物歧化酶;同时,那些铁原子附近的踪迹残基跟铁的绑定和催化功能直接相关.
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| 关 键 词： | 超氧化物歧化酶 腾冲嗜热厌氧菌 同源建模 进化踪迹分析 分子动力学 |
| 文章编号： | 1000-2537（2007）04-0110-04 |
| 收稿时间： | 2007-04-14 |
| 修稿时间： | 2006年4月14日 |
Evolutionary Trace Analysis of Superoxide Dismutase from Thermoanaerobacter tengcongensis |
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| LIU Yuan-dong,LIU Chu-gan,DING Jian-nan,QIU Guan-zhou.Evolutionary Trace Analysis of Superoxide Dismutase from Thermoanaerobacter tengcongensis[J].Journal of Natural Science of Hunan Normal University,2007,30(4):110-113. |
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| Authors: | LIU Yuan-dong LIU Chu-gan DING Jian-nan QIU Guan-zhou |
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| Institution: | 1. School of Resources Processing and Bioengineering, Central South University, Changsha 410053, China 2. Central Primary School of Langshan Town, Xinning County, Hunan Province, Shaoyang 422702, China |
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| Abstract: | With homology modeling techniques and molecular dynamics simulations,a reliable molecular structure of the protein encoded by the gene sod from Thermoanaerobacter tengcongensis was built.Evolutionary trace analysis on this modeled structure reveal 11 trace residues.Among them,the residues of Asn36,Gly101and Glu158 are randomly scattered throughout the mapped structure;the other residues are all distinctly clustered in a subgroup near Fe atom. From these results,this gene encodes a Fe-depending superoxide dismutase.Furthermore,the trace residues around Fe atom are directly responsible for Fe binding and catalytic function. |
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| Keywords: | superoxide dismutase Thermoanaerobacter tengcongensis homology modeling evolutionary trace molecular dynamics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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