Evidence that superoxide radicals are involved in the hemolytic mechanism of phenylhydrazine |
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| Authors: | A. Valenzuela H. Ríos G. Neiman |
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| Affiliation: | (1) Laboratorio de Bioquímica, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Casilla 15138, Santiago 11, Chile;(2) Present address: Facultad de Medicina-Sur, Departamento de Ciencias Médico Biológicas y Básicas, Universidad de Chile, Santiago, Chile |
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| Abstract: | Summary Phenylhydrazine produces in the red blood cell the same effect as the enzymic system xanthine oxidase-xanthine, a superoxide radical generator system. Both effects are inhibited by the enzyme superoxide dismutase.This work was supported in part by grants Nos. 1045 and 3243 of Oficina Técnica de Desarrollo Científico y Creación Artística de la Universidad de Chile. |
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