Ultrastructural changes in dog thyroid follicular cells elicit by concanavalin A in vitro |
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| Authors: | J. A. Fernandez-Pol J. P. Binette M. T. Hays |
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| Affiliation: | (1) Laboratory of Electron Microscopy, Veterans Administration Hospital, Buffalo, New York, 14215;(2) Department of Medicine and Nuclear Medicine of the State University of New York at Buffalo, 14214 Buffalo, New York, USA |
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| Abstract: | Summary Dog thyroid follicular cells exposed to concanavalin A (Con A) in vitro showed changes in cell shape, induction of colloid droplets and alterations in the distribution of microvilli. Cells exposed to Con A plus suboptimal concentrations of TSH (thyroid stimulating hormone) showed pseudopods and their cytoplasm was virtually occupied with colloid droplets. This findings suggest that Con A potentiated pseudopod and colloid droplet formation induced by TSH.Acknowledgments. The authors gratefully acknowledge the expert technical assistance of J. M. Greco. Supported by V. A. Research Funds. |
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