An electrochemical and Raman spectroscopic study on involvement of La3+ ions in lactate dehydrogenase catalysis |
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| Authors: | Xunqing Wang Zhenhua Xu Xiaoxia Gao |
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| Institution: | WANG Xunqing, XU Zhenhua and GAO Xiaoxia * College of Chemistry and Molecular Engineering , Peking University, Beijing 100871, China. * Corresponding author |
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| Abstract: | The influence of La 3+ on lactate dehydrogenase catalysis was investigated by electrochemical and FT-Raman techniques. The results showed that La 3+ ions bind preferably with phosphate moiety and ribose group (3′-OH) connected to nicotinamide in coenzyme NAD +/NADH, destabilize the enzyme-coenzyme complex and inhibit LDH activity. |
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| Keywords: | La 3+ ion LDH catalysis electrochemistry FT-Raman technique |
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