Modification of radiation response by agents that elevate the intracellular c-AMP level

Summary A study has been made of the effects of drugs known to elevate c-AMP level on radiation-induced damage in thymocytes. The test used was the ability of the cells to exclude dye. -receptor stimulation and phosphodiesterase inhibition were found to induce radioresistance. The possible importance of the plasma membrane in connection with cytoplasmic factors is briefly discussed.Supported by International Atomic Energy Agency contract 2175/RB, PNUD Grant 102/77 and UACH Grant S-79-2.We thank Dr E. Ortega for the irradiation facilities.