Enzymatic synthesis of trisialoganglioside by particulate fractions of rat liver |
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| Authors: | Carol L Richardson W D Merritt T W Keenan D James Morré |
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| Institution: | (1) Department of Biological Sciences, Medicinal Chemistry and Pharmacognosy, and Animal Sciences, Purdue University, 47907 West Lafayette, Indiana, USA |
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| Abstract: | Summary Rat liver contains a particulate (membrane-bound) glycosyl transferase, concentrated in Golgi apparatus fractions, which catalyzes the synthesis of a trisialoganglioside from the ganglioside precursor disialohematoside (GD3). Sialic acid was not incorporated into exogenous GD1a from CMP-N-acetylneuraminic acid suggesting that GD1a is an endproduct of the monosialoganglioside pathway. Thus, the disialoganglioside pathway may be a primary source of trisialoganglioside and higher ganglioside homologs in adult rat liver. |
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