Tumorigenic effect of topical mechlorethamine,BCNU and CCNU in mice |
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| Authors: | H S Zackheim E A Smuckler |
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| Institution: | (1) Departments of Dermatology and Pathology, University of California Medical Center, 94143 San Francisco, California, USA |
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| Abstract: | Summary Mice were painted with mechlorethamine (HN2), carmustine (BCNU) and lomustine (CCNU) for up to 33 weeks. HN2 was a potent carcinogen, producing squamous cell carcinomas in 9 of 33 mice in 1 series. BCNU was a weak carcinogen. CCNU produced no tumors in 1 series.Supported in part by PHS grant CA-14825 from the National Cancer Institute. |
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