| 天然产物来源的黄嘌呤氧化酶抑制剂研究进展 |
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| 引用本文： | 谭明亮,陈刚. 天然产物来源的黄嘌呤氧化酶抑制剂研究进展[J]. 渝州大学学报(自然科学版), 2014, 0(2): 86-90 |
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| 作者姓名： | 谭明亮 陈刚 |
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| 作者单位： | 重庆工商大学药物化学与化学生物学研究中心,重庆400067 |
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| 摘 要： | 高尿酸血症及痛风是当今社会的常见病、多发病,至今无法根治.尽管临床常用的降尿酸药物,如别嘌呤醇疗效确切,但副作用大,使其应用受到明显限制,故寻找新的安全、高效的降尿酸活性物质一直是研究热点之一；黄嘌呤氧化酶（xanthine oxidase,XOD）是介导尿酸生成的重要酶；旨在对天然产物提取物、活性部位和单体成分抑制黄嘌呤氧化酶活性的研究成果进行综述.
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| 关 键 词： | 黄嘌呤氧化酶 天然产物 高尿酸血症 痛风 |
Research Progress in Xanthine Oxidase Inhibitor from Natural Products |
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| TAN Ming-liang,CHEN Gang. Research Progress in Xanthine Oxidase Inhibitor from Natural Products[J]. Journal of Yuzhou University(Natural Sciences Edition), 2014, 0(2): 86-90 |
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| Authors: | TAN Ming-liang CHEN Gang |
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| Affiliation: | (Research Center for Medical Chemistry and Chemical Biology, Chongqing Technology and Business University, Chongqing 400067, China) |
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| Abstract: | Hyperuricemia and gout are common and frequently-occuring diseases and can not be cured currently.Although frequently-used clinical hypouricemic medicine, allopurinol, has notably curing effect, its side- effect is serious, and its application is obviously restricted. As a result, it has been a hot point to search for hypouricemic medicines with high activity and low toxicity.Xanthine Odidase is an important enzyme to catalyze the production of uric acid.This paper aims to review the research achievement for the extraction of natural products and the inhibition of Xanthine Oxidase activity by active site and monomer components. |
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| Keywords: | Xanthine Oxidase natural product hyperuricemia gout |
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