Inhibition of mushroom tyrosinase by 3-amino-L-tyrosine: molecular probing of the active site of the enzyme |
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| Authors: | J F Maddaluno K F Faull |
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| Institution: | Nancy Pritzker Laboratory of Behavioral Neurochemistry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305. |
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| Abstract: | We report the ability of 3-amino-L-tyrosine to act as a fully reversible competitive inhibitor of mushroom tyrosinase. The inhibition is linked to the ortho-aminophenol structure, and a copper bridging mechanism in the active site is proposed. |
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