| Abstract: | Pluripotent stem cells hold tremendous promise for regenerative medicine. The mechanisms underlying the acquisition and loss of pluripotency have been revealed at multiple levels. Subcellular mechanisms such as metabolic and organelle remodeling are emerging as critical for pluripotent cell fate transitions. Understanding the rules and roles of organelle remodeling will not only provide important insights into pluripotency regulation, but also help improving application in regenerative medicine. In this review, we summarize recent discoveries in organelle remodeling during the acquisition and loss of pluripotency and discuss how membrane lipids orchestrate organelle remodeling and drive nuclear gene expression. |
