Production of passive cutaneous anaphylaxis (PCA) and reversed PCA by rat IgE antibody in the mouse |
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Authors: | M Harada M Nagata M Takeuchi |
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Institution: | (1) Shionogi Research Laboratories, Shionogi & Co., Ltd., Fukushima-ku, 553 Osaka, (Japan) |
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Abstract: | Summary Although IgE antibody is generally characterized as a homocytotropic antibody, it has been well known for some time that mouse IgE antibody causes potent sensitization of rat skin for PCA. The present study clearly shows, the reciprocal cross-sensitization of mouse skin with rat IgE molecules. PCA and RPCA were produced by rat IgE antibody in an inbred mouse strain, DS/Shi, though not in C3H/HeShi, C57BL/6JShi and BALB/cCrj strains. Sensitization of DS/Shi mouse skin for PCA with rat IgE antibody was comparable in sensitivity with that of rat skin, but lasted only for a short term in comparison with the long persistence in rat skin. |
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Keywords: | PCA reversed PCA rat IgE antibody DS/Shi mouse |
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