Evolutionary genomics: detecting selection needs comparative data |
| |
Authors: | Nielsen Rasmus Hubisz Melissa J |
| |
Institution: | Centre for Bioinformatics, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark. rasmus@binf.ku.dk |
| |
Abstract: | Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al. describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|