Acute toxicity of dimethylnitrosamine in the presence of inhibitors of DMN demethylase |
| |
Authors: | M A Friedman Virginia Sanders |
| |
Institution: | (1) Department of Pharmacology, Medical College of Virginia, Health Sciences Division, Virginia Commonwealth University, 23298 Richmond, Virginia, USA |
| |
Abstract: | Summary The LD50 of DMN was determined in groups of mice in the presence of inhibitors of DMN demethylase. Piperonyl butoxide, dibutylnitrosamine and nitrososarcosine had no effect on the acute toxicity of DMN. Diethylnitrosamine and DMN were markedly synergistic. All mice treated with 100 mg/kg diethylnitrosamine and 10.7 mg/kg DMN died. These results suggest that DMN demethylase may not be involved in theaacute toxicity of DMN.We thank Dr.D. B. Couch, Mr.E. J. Greene and Dr.A. E. Munson for their technical assistance. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|