Inhibition of collagen synthesis by interleukin-1 in three-dimensional collagen lattice cultures of fibroblasts |
| |
Authors: | P Gillery F Coustry J P Pujol J P Borel |
| |
Affiliation: | Lab. Biochemistry, UA CNRS 610, Fac. Medicine, Reims, France. |
| |
Abstract: | Interleukin-1 (Il-1) was added to collagen lattice cultures of human skin fibroblasts. No cell division was induced, the ability of fibroblasts to contract the lattices was decreased and a dose-related inhibition of collagen synthesis without effect on non-collagen proteins was found. Indomethacin had no influence on these effects. |
| |
Keywords: | |
|
|