Inhibition of collagen synthesis by interleukin-1 in three-dimensional collagen lattice cultures of fibroblasts |
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| Authors: | P Gillery F Coustry J P Pujol J P Borel |
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| Institution: | Lab. Biochemistry, UA CNRS 610, Fac. Medicine, Reims, France. |
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| Abstract: | Interleukin-1 (Il-1) was added to collagen lattice cultures of human skin fibroblasts. No cell division was induced, the ability of fibroblasts to contract the lattices was decreased and a dose-related inhibition of collagen synthesis without effect on non-collagen proteins was found. Indomethacin had no influence on these effects. |
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