番茄红素对糖尿病大鼠骨质的影响

研究番茄红素对小剂量多次腹腔注射链脲佐菌素所致糖尿病大鼠骨质的影响.用链脲佐菌素以30mg/kg注射Wister雄性大鼠6周,成功建立糖尿病模型;对正常对照组、糖尿病模型组、番茄红素组和胰岛素治疗组进行骨常规参数进行测定及比较.糖尿病模型组骨密度、骨结构力学参数、生物力学参数、骨钙、镁、锰及羟脯氨酸含量均比青年组有显著降低(P<0.01),而骨磷含量、骨和血清碱性磷酸转移酶均比正常对照组有显著升高(P<0.01);相比之下,番茄红素组在上述参数指标方面均与糖尿病模型组呈现显著差异(P<0.01),与胰岛素治疗组呈现相同作用趋势,但效果不如后者.研究表明长期摄入番茄红素可减少小剂量多次腹腔注射链脲佐菌素大鼠糖尿病的发病率,进而影响糖尿病大鼠骨质变化的发生.

Influence on Osseous Changes of Diabetic Rat by Lycopene

Evaluation of the effects of lycopene on osseous change of diabetic rats induced by streptozotocin(STZ)injected at several low dosages were made.Injections of STZ for six weeks to set mode of the diabetic rats.They were randomly divided in four groups,including control group,diabetic model group,lycopene group and insulin-treated diabetic group,whose osseous routine parameters were tested and compared.Compared with control group,the bone mineral density(BMD),structural power parameters of bone,biological power parameters of bone,bone calcium,manganese,magnesium and the content of hydroxyproline in the diabetic model group were significantly decreased(P<0.01).And the content of bone phosphorus,the activity of bone and serum alkaline phosphatase(ALP)were significantly raised(P<0.01).Moreover,it is significantly different between lycopene group and diabetic model group in these parameters(P<0.01).But the cured effect of insulin-treated diabetic group was better than the lycopene group.Lycopene can reduce the incidence of diabetes in rats induced by streptozotocin at several low dosages,and reform the osseous change of diabetic rat.