Synthetic RNA-dependent DNA polymerase activity in normal rat liver and hepatomas |
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| Authors: | Ward D C Humphryes K C Weinstein I B |
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| Institution: | Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London WC2. |
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| Abstract: | Normal adult rat liver contains a high level of a synthetic RNA-dependent DNA polymerase activity, which is distinct from cellular DNA-dependent polymerases. It uses poly(dT).poly(rA) and poly(rA).poly(rU) as templates but has little or no response to DNA or several single-stranded RNAs. |
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