Specific immunosuppression of IgE response to hapten DNP by DNP linked to monoclonal IgG1 in rats |
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| Authors: | D Pan M -S Shiao |
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| Institution: | (1) Department of Physiological Chemistry, University of Wisconsin, and William S. Middleton Memorial Veterans Hospital, Lipid Metabolism Laboratory, 53705 Madison, Wisconsin, USA;(2) Department of Immunology, Faculty of Medicine, The University of Manitoba, Winnipeg, Manitoba, Canada;(3) Biological Research Institute, Academia Sinica, Taipei, (Taiwan);(4) Present address: Immunology Laboratory Department of Laboratories, Foothills Hospital, Calgary, Alberta, Canada |
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| Abstract: | Summary The induction of the anti-DNP IgE in rat was suppressed by pretreatment of rats with the tolerogen synthesized by coupling DNP to rat IgG, i.e.; DNP7–10-IgG. It was found that DNP10-IgG1 was an effective tolerogen, whereas other DNP conjugates, i.e. DNP9-IgM, DNP9-IgA, DNP10-IgE, DNP10-IgG2c and DNP10-IgG2a were ineffective.This work was partly supported by a research grant from the Medical Council of Canada to W.Y.L. |
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